The incidence of diabetes mellitus is reportedly on the rise, especially in the developing countries, and it is estimated that these countries will witness a 69% increase between 2010 and 2030. A high cost of medical care of diabetes is forcing an increasing number of people into the use of herbal alternatives for cure. Till now, so many researchers have evaluated many plants for their antihyperglycemic and antihyperlipidemic activities. However, still, we are lacking to prepare effective ayurvedic dosage form which can complete the allopathic drugs. This difficulty can be overcome using the synergism. Synergism can be defined as the interaction or cooperation of two or more substances to produce a combined effect greater than of their separate effects. Hence, in this present study, we therefore assessed the combinatorial effect of the extracts of fresh fruit of Lagenaria siceraria and Eulophia herbacea in diabetic rats. The significant reduction of glucose and lipid levels in combinatorial extracts was superior as compared with the respective monotherapies. Finally, the combinatorial effect of extracts proved the hypothesis of the synergistic effect of selected plants.